DNA-repair gene variants are associated with glioblastoma survival
نویسندگان
چکیده
منابع مشابه
SSBP2 variants are associated with survival in glioblastoma patients.
PURPOSE Glioblastoma is a devastating, incurable disease with few known prognostic factors. Here, we present the first genome-wide survival and validation study for glioblastoma. EXPERIMENTAL DESIGN Cox regressions for survival with 314,635 inherited autosomal single-nucleotide polymorphisms (SNP) among 315 San Francisco Adult Glioma Study patients for discovery and three independent validati...
متن کاملPolymorphisms in the interleukin-4 receptor gene are associated with better survival in patients with glioblastoma.
PURPOSE Previous literature provides some evidence that atopic diseases, IgE levels, and inflammatory gene polymorphisms may be associated with risk of glioblastoma. The purpose of this study was to investigate the effects of certain inflammatory gene single nucleotide polymorphisms (SNP) on patient survival. Malignant gliomas are the most common type of primary brain tumor in adults, however, ...
متن کاملDNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population
BACKGROUND Interactions between genetic variants and risk factors in myelodysplastic syndromes are poorly understood. In this case-control study, we analyzed 1 421 single nucleotide polymorphisms in 408 genes involved in cancer-related pathways in 198 patients and 292 controls. METHODS The Illumina SNP Cancer Panel was used for genotyping of samples. The chi-squared, p-values, odds ratios and...
متن کاملGenetic variants of nucleotide excision repair genes are associated with DNA damage in coke oven workers.
We explored the effects of single nucleotide polymorphisms (SNP) of nucleotide excision repair (NER) genes on DNA damage caused by exposure to carcinogenic polycyclic aromatic hydrocarbons (PAH) in 475 Chinese workers. We quantified urinary 1-hydroxypyrene using high-performance liquid chromatography, and the DNA damage level of lymphocytes was examined by the comet assay and represented as the...
متن کاملDNA repair gene variants associated with benign breast disease in high cancer risk women.
Benign breast disease (BBD) is a risk factor for breast cancer and may have a heritable component. Deficient DNA repair has been implicated in breast cancer etiology and may exert its effect before BBD, a known precursor. The association between allelic variants in DNA repair genes and BBD was examined in a cohort of women in Washington County, Maryland. BBD was defined by two criteria: (a) a p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Oncologica
سال: 2011
ISSN: 0284-186X,1651-226X
DOI: 10.3109/0284186x.2011.616284